Kathleen Ryan

Kathleen Ryan

Anand Ranjan

Anand Ranjan

Associate Research Scientist

Selected Publications:
Wang F, Ranjan A, Wei D, Wu C. (2016) Comment on "A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme". Science 353(6297):358, PMID: 27463665. [ pdf ]
Liang X, Shan S, Pan L, Zhao J, Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C, Zhou, Z. (2016) Structural basis of H2A.Z recognition by SRCAP chromatin remodelling subunit YL1. Nat Struct Mol Biol. 23(4):317-23. Epub Mar 14. [ pdf ]
Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y. (2014) The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer. Mol Cell. 53:498-505. [ pdf ]
Ranjan A, Wang F, Wei D, Huang Y, Wu C. (2015) Nucleosome H2A histone fold and DNA elements activate SWR1-mediated H2A.Z replacement. eLIFE June 27. [ pdf ]
Nguyen VQRanjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. (2013) Molecular Architecture of the ATP-Dependent Chromatin-Remodeling Complex SWR1. Cell 154:1220-31. [ pdf ]
Ranjan AMizuguchi G, Fitzgerald PC, Wei D, Wang F, Huang Y, Luk E, Woodcock CL, Wu C. (2013) Nucleosome-free Region Dominates Histone Acetylation in Targeting SWR1 to Promoters for H2A.Z Replacement. Cell 154:1232-45. [ pdf ]

Gaku Mizuguchi

Gaku Mizuguchi

Principle Research Scientist

Selected Publications:
Ranjan AMizuguchi G, Fitzgerald PC, Wei D, Wang F, Huang Y, Luk E, Woodcock CL, Wu C. (2013) Nucleosome-free Region Dominates Histone Acetylation in Targeting SWR1 to Promoters for H2A.Z Replacement. Cell 154:1232-45. [ pdf ]

Yanshu Wang

Yanshu Wang

Selected Publications:
Cho, C., Wang, Y., Smallwood, P.M., Williams, J., Nathans, J. (2019) Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.  eLife 8: e47300. [ pdf ]
Wang, Y., Sabbagh, M.F.,  Gu, X., Rattner, A., Willia ms, J., and Nathans, J. (201 9) Beta-catenin signaling regu lates barrier-specific gene expression in circumventricular organ and ocular vasculatures.  eLife 8: e43257. [ pdf ]
Wang, Y., Cho, C., Williams, J., Smallwood, P.M., Zhang, C.,  Junge, H.J., and Nathans, J. (2018) Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences USA 15: E11827-E11836. [ pdf ]
Wang, Y., Chang, H., Rattner, A., and Nathans, J. (2016) Frizzled receptors in development and disease. Current Topics in Developmental Biology 117: 113-139. [ pdf ]
Wang, Y., Williams, J., Rattner, A., Wu, S., Bassuk, A.G., Goffinet, A.M., and Nathans, J. (2016) Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling.  Developmental Biology 419: 298-310. [ pdf ]
Chang, H., Cahill, H., Smallwood, P.M., Wang, Y., and Nathans, J. (2015) Identification of Astrotactin2 as a genetic modifier that regulates the global orientation of mammalian hair follicles. PLOS Genetics 11: e1005532. [ pdf ]

Dominique Rasoloson

Dominique Rasoloson

Selected Publications:
Alexandre Paix, Dominique Rasoloson, Andrew Folkmann, and Geraldine Seydoux (2019). Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors. Current Protocols in Molecular Biologu e102, Volume 129. [ link ]
Paix A, Folkmann A, Goldman DH, Kulaga H, Grzelak MJ, Rasoloson D, Paidemarry S, Green R, Reed RR, Seydoux G. (2017) Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. Proc Natl Acad Sci U S A. (2017) Dec 12;114(50):E10745-E10754. [ link ]
Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH. (2017) MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes. Genetics Oct;207(2):447-463.  [ link ]
Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G. (2016) Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. eLife 2016;10.7554/eLife.21337. [ link ]
Paix A, Folkmann A, Rasoloson D, Seydoux G. (2015) High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics 201(1):47-54. [ pdf ]
Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G. (2014) Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife Dec 23;3:e04591. [ link ]

Suzi Sebald

Suzi Sebald

Selected Publications:
Lee YS, Lehar A, Sebald S, Liu M, Swaggart KA, Talbot CC Jr, Pytel P, Barton ER, McNally EM, Lee SJ. (2015) Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Human Molecular Genetics 24:(20):5711-9.  [ pdf ]

Margaret Strong

Margaret Strong

Selected Publications:
Pike AM, Strong MA, Ouyang JPT, Greider CW. (2019) TIN2 functions with TPP1/POT1 to stimulate telomerase processivity. American Society for Microbiology ASM:doi: https://doi.org/10.1128/MCB.00593-18. [ link ] [ pdf ]
Jonathan K. Alder, Vidya Sagar Hanumanthu, Margaret A. Strong, Amy E. DeZern, Susan E. Stanley, Clifford M. Takemoto, Ludmilla Danilova, Carolyn D. Applegate, Stephen G. Bolton, David W. Mohr, Robert A. Brodsky, James F. Casella, Carol W. Greider, J. Brooks Jackson and Mary Armanios. (2018) Diagnostic utility of telomere length testing in a hospital-based setting. PNAS 115 (10): E2358-E2365 [ link ] [ pdf ]
Wang, S., Pike, A. M., Lee, S. S., Strong, M.A., Connelly, C.J., Greider, C.W. (2017) BRD4 inhibitors block telomere elongation. Nucleic Acids Research. 45(14): 8403-8410.  [ link ] [ pdf ]
Strong MA, Vidal-Cardenas SL, Karim B, Yu H, Guo N, Greider CW. (2011) Phenotypes in mTERT+/- and mTERT-/- Mice are Due to Short Telomeres, Not Telomere-Independent Functions of TERT. Molecular and Cellular Biology 31: 2369-2379. [ link ]
Hemann, M.T., Strong, M., Hao, L.-Y., and Greider, C.W. (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 66-77. [ pdf ]

Carla Connelly

Carla Connelly

Selected Publications:
Wang, S., Pike, A. M., Lee, S. S., Strong, M.A., Connelly, C.J., Greider, C.W. (2017) BRD4 inhibitors block telomere elongation. Nucleic Acids Research. 45(14): 8403-8410.  [ link ] [ pdf ]
Kaizer H, Connelly CJ, Bettridge K, Viggiani C, Greider CW. (2015) Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae. Genetics 201:573-586. [ pdf ]
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