2016

Urban S. (2016) Cartography of intramembrane proteolysis. Cell 167(7):1898. [ link ]
Smith J, Calidas D, Schmidt H, Lu T, Rasoloson D, Seydoux G. (2016) Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. eLife 2016;10.7554/eLife.21337. [ link ]
Wang F, Ranjan A, Wei D, Wu C. (2016) Comment on "A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme". Science 353(6297):358, PMID: 27463665. [ pdf ]
Lambrus, B.G., Daggubati, V., Uetake, Y., Scott, P.M., Clutario, K.M., Sluder, G., Holland, A.J. (2016) A USP28-53BP1-p53-p21 signaling axis arrests growth following centrosome loss or prolonged mitosis. Journal of Cell Biology 214:143-153. [ link ] [ pdf ]
Greider, C.W. (2016) Regulating telomere length from the inside out: the replication fork model. Genes & Development 30(13):1483-1491.   [ pdf ]
Liang X, Shan S, Pan L, Zhao J, Ranjan A, Wang F, Zhang Z, Huang Y, Feng H, Wei D, Huang L, Liu X, Zhong Q, Lou J, Li G, Wu C, Zhou, Z. (2016) Structural basis of H2A.Z recognition by SRCAP chromatin remodelling subunit YL1. Nat Struct Mol Biol. 23(4):317-23. Epub Mar 14. [ pdf ]
Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D. (2016) Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell, 36: 246-248.   [ pdf ]
Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y. (2014) The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer. Mol Cell. 53:498-505. [ pdf ]
Cho S, Dickey SW, Urban S. (2016) Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Molecular Cell 61(3):329-40. [ link ] [ pdf ]
Abrahamsson S, Ilic R, Wisniewski J, Mehl B, Yu L, Chen L, Davanco M, Oudjedi L, Fiche J, Hajj B, Jin X, Pulupa J, Cho C, Mir M, El Beheiry M, Darzacq X, Nollmann M, Dahan M, Wu C, Lionnet T, Liddle A, Bargmann C. (2016) Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging. Biomedical Optics Express 7(3):855-869. [ pdf ]

2015

Lee, S, S., Bohrson, C. Pike, A.M., Whellan, S.J., and Greider, C.W. (2015) ATM kinase is required for telomere elongation in mouse and human cells. Cell Reports 13(8):1623-1632. [ pdf ]
Paix A, Folkmann A, Rasoloson D, Seydoux G. (2015) High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics 201(1):47-54. [ pdf ]
Sun GJ, Zhou Y, Stadel RP, Moss J, Yong JH, Ito S, Kawasaki NK, Phan AT, Oh JH, Modak N, Reed RR, Toni N, Song H, Ming GL. (2015) Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain. Proceedings of the National Academy of Sciences USA 112(30):9484-9. [ pdf ]
Buhr ED, Yue WW, Ren X, Jiang Z, Liao HW, Mei X, Vemaraju S, Nguyen MT, Reed RR, Lang RA, Yau KW, Van Gelder RN. Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. (2015) Proceedings of the National Academy of Sciences USA. 112(42):13093-8.  [ pdf ]
Sun LO, Brady CM, Cahill H, Al-Khindi T, Sakuta H, Dhande OS, Noda M, Huberman AD, Nathans J, Kolodkin AL. (2015) Functional assembly of accessory optic system circuitry critical for compensatory eye movements. Neuron 86(4):971-84.  [ pdf ]
Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY. (2015) Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Elife 4. doi: 10.7554/eLife.06489. [ pdf ]
Mo A, Mukamel EA, Davis FP, Luo C, Henry GL, Picard S, Urich MA, Nery JR, Sejnowski TJ, Lister R, Eddy SR, Ecker JR, Nathans J. (2015) Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain. Neuron 86(6):1369-84.  [ pdf ]
Hua ZL, Emiliani FE, Nathans J. (2015) Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems. Neural Development 10(1):21.  [ pdf ]
Chang H, Cahill H, Smallwood PM, Wang Y, Nathans J. (2015) Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. PLoS Genetics 11(9):e1005532.  [ pdf ]
DiGirolamo DJ, Singhal V, Chang X, Lee SJ, Germain-Lee EL. (2015) Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta. Bone Research Feb 10;3:14042. [ pdf ]
Lee YS, Lehar A, Sebald S, Liu M, Swaggart KA, Talbot CC Jr, Pytel P, Barton ER, McNally EM, Lee SJ. (2015) Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Human Molecular Genetics 24:(20):5711-9.  [ pdf ]
Zheng Y, Wang W, Liu B, Deng H, Uster E, and Pan D. (2015) Identification of Happyhour/MAP4K as alternative Hpo/Mst-like kinases in the Hippo kinase cascade. Developmental Cell, 34: 642-655. [ link ] [ pdf ]
Cai, J., Maitra, A., Anders, R.A., Taketo, M.M., and Pan, D. (2015) beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes & Devopment., 29: 1493-1506. [ pdf ]
Chen Q, Zhang, N., Xie R, Wang W, Cai J, Choi KS, David KK, Huang B, Yabuta N, Nojima H, and Pan D. (2015) Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes & Development., 29: 1285-1297. [ pdf ]
Deng H, Wang W, Yu J, Zheng Y, Qing Y, and Pan D. (2015) Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. eLife, Mar 31:e06567. doi: 10.7554/eLife.06567.  [ pdf ]
Kaizer H, Connelly CJ, Bettridge K, Viggiani C, Greider CW. (2015) Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae. Genetics 201:573-586. [ pdf ]
Koutmou KS, Schuller AP, Brunelle JL, Radhakrishnan A, Djuranovic S, Green R. (2015) Ribosomes slide on lysine-encoding homopolymeric A stretches. Elife 4 doi: 10.7554/eLife.05534. [ pdf ]
Woolstenhulme CJ, Guydosh NR, Green R, Buskirk AR. (2015) High-precision analysis of translational pausing by ribosome profiling in bacteria lacking EFP. Cell Reports 11(1):13-21. [ pdf ]
Kowalinski E, Schuller A, Green R, Conti E. (2015) Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases. Structure 23(7):1336-43. [ pdf ]
Young DJ, Guydosh NR, Zhang F, Hinnebusch AG, Green R. (2015) Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo. Cell 162(4):872-84. [ pdf ]
Arthur L, Pavlovic-Djuranovic S, Smith-Koutmou K, Green R, Szczesny P, Djuranovic S. (2015) Translational control by lysine-encoding A-rich sequences. Science Advances 1(6): soi:10.1126/sciadv. 1500154. [ pdf ]
Lu C, Ward A, Bettridge J, Liu Y, Desiderio S. (2015) An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation. Cell Reports 10(1): 29-38. [ pdf ]
Zordan RE, Beliveau BJ, Trow JA, Craig NL, Cormack BP. (2015) Avoiding the ends: internal epitope tagging of proteins using transposon Tn7. Genetics 200(1):47-58. [ pdf ]
Li CX, Gleason JE, Zhang SX, Bruno VM, Cormack BP, Culotta VC. (2015) Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase. Proceedings of the National Academy of Sciences USA 112:38, E5336-E5342. [ pdf ]
Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ. (2015) p53 protects against genome instability following centriole duplication failure. Journal of Cell Biology 210(1), 63-77. [ pdf ]
Baker RP, Urban S. (2015) Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating. Nature 523, 101–105. [ link ]
Ranjan A, Wang F, Wei D, Huang Y, Wu C. (2015) Nucleosome H2A histone fold and DNA elements activate SWR1-mediated H2A.Z replacement. eLIFE June 27. [ pdf ]
Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ. (2015) STIL binding to Plk4 activates kinase activity to promote centriole duplication. Journal of Cell Biology. 209(6), 863-78. [ pdf ]
Kim J, Duan R, Jin P, Chen EH. (2015) Mechanisms of myoblast fusion during muscle development. Current Opinion in Genetics and Development. 32, 162-170. [ pdf ]
Kim JH, Ren Y, Ng WP, Li S, Son S, Kee Y, Zhang S, Zhang G, Fletcher DA, Robinson DN, Chen EH. (2015) Mechanical tension drives cell membrane fusion. Developmental Cell 32, 561-73. [ pdf ]

2014

Wang JT, Smith J, Chen BC, Schmidt H, Rasoloson D, Paix A, Lambrus BG, Calidas D, Betzig E, Seydoux G. (2014) Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife Dec 23;3:e04591. [ link ]
Hajj B, Wisniewski J, El Beheiry M, Chen J, Revyakin A, Wu C, Dahan M. (2014) Whole-cell, multicolor super-resolution imaging using volumetric multifocus microscopy. Proc Natl Acad Sci U S A. 111:17480-5. [ pdf ]
Zhou Y, Nathans J. (2014) Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical Wnt signaling. Developmental Cell 31: 248-256. [ link ]
Chen M, Tian S, Yang X, Lane AP, Reed RR, Liu H. (2014) Wnt-responsive Lgr5⁺ globose basal cells function as multipotent olfactory epithelium progenitor cells. Journal of J Neurosci. 34(24):8268-76.    [ pdf ]
Qing Y, Yin F, Wang W, Zheng Y, Guo P, Schozer F, Deng H, and Pan D. (2014) The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. eLife, Jul 15:e02564. doi: 10.7554/eLife.02564. [ pdf ]
Chen Q, Zhang N, Gray RS, Li H, Ewald AJ, Zahnow CA, and Pan D. (2014) A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis. Genes & Development., 28: 432-437. [ pdf ]
Hua ZL, Chang H, Wang Y, Smallwood PM, Nathans J. (2014) Partial interchangeability of Frizzled3 and Frizzled6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development 141: 3944-3954. [ link ]
Urban S, Moin SM. (2014) A subset of membrane-altering agents and gamma-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases. Cell Reports 8, 1241–1247. [ link ]
Zhou Y, Wang Y, Tischfield M, Williams J, Smallwood PM, Rattner A, Taketo MM, Nathans J. (2014) Canonical Wnt signaling components in vascular development and barrier formation. Journal of Clinical Investigation 124: 3825-3846. [ link ]
Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss A-L, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F. (2014) Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica. Cell 158, 353–367. [ link ] [ pdf ]
Hua ZL, Jeon S, Caterina M, Nathans J. (2014) Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proceedings of the National Academy of Sciences USA 111: E3005-3014. [ link ]
Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW. (2014) High-sensitivity measurements of multiple kinase activities in live single cells. Cell 157(7):1724-34. [ link ]
Wu H, Williams J, Nathans J. (2014) Complete morphologies of basal forebrain cholinergic neurons in the mouse. eLife 3:e02444. [ link ]
Koutmou KS, McDonald ME, Brunelle JL, Green R. (2014) RF3:GTP promotes rapid dissociation of the class 1 termination factor. RNA May;20(5):609-20. [ link ]
Macia J*, Regot S*, Peeters T, Conde N, Solé R, Posas F. (2009) Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Science Signaling Mar 24;2(63):ra13. [ link ]
Wisniewski J, Hajj B, Chen J, Mizuguchi G, Xiao H, Wei D, Dahan M, Wu C. (2014) Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres. eLIFE May 20. [ pdf ]
Guydosh NR, Green R. (2014) Dom34 rescues ribosomes in 3' untranslated regions. Cell Feb 27;156(5):950-62. [ link ]
Wu H, Luo J, Yu H, Rattner A, Mo A, Wang YSmallwood PM, Erlanger B, Wheelan SJ, Nathans J. (2014) Cellular resolution maps of X-chromosome inactivation: implications for neural development, function, and disease. Neuron 81: 103-119. [ link ]
Zaher HS, Green R. (2014) In vitro synthesis of proteins in bacterial extracts. Methods in Enzymology 539:3-15. [ link ]

2013

Hua L, Smallwood PM, Nathans J. (2013) Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. eLife 2: e01482. [ link ]
Dickey WS, Baker RP, Cho S, Urban S. (2013) Proteolysis inside the membrane is a rate-governed reaction not driven by substrate affinity. Cell 155, 1270–1281. [ pdf ]
Kwon I, Kato M, Xiang S, Wu L, Theodoropoulos P, Mirzaei H, Han T, Xie S, Corden JL, McKnight SL. (2013) Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains. Cell 155, 1049-1060. [ link ]
Yin F, Yu J, Zheng Y, Chen Q, Zhang N, and Pan D. (2013) Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (154): 1342-1355. [ pdf ]
Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D. (2013) The Hippo effector Yorkie controls normal tissue growth by antagnozing scalloped-mediated default repression. Developmental Cell 25(4):388-401. [ link ] [ pdf ]
Shilagardi K, Li S, Luo F, Marikar F, Duan R, Jin P, Kim J, Murnen K, Chen EH. (2013) Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. Science 340(6130):359-363. [ link ]
Wright JA, Smith RC, Li X, Craig NL, Atkinson PW. (2013) IPB7 transposase behavior in Drosophila melanogaster and Aedes aegypti. Insect Biochemistry and Molecular Biology 43:899-906. [ link ]
Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SIS, Craig NL, Levin HL. (2013) Profiles of transposon integration detect nucleosome arrays and identify the essential genes of Schizosaccharomyces pombe. Genetics 195(2):599-609. [ link ]
Sharma T, Reed RR. (2013). Balancing Survival: The role of CTGF in controlling experience-modulated olfactory circuitry. Neuron 79(6), 1037-1039. [ pdf ]
Corden JL. (2013) RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chemical Reviews 113, 8423-8455. [ link ]
Nguyen VQRanjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. (2013) Molecular Architecture of the ATP-Dependent Chromatin-Remodeling Complex SWR1. Cell 154:1220-31. [ pdf ]
Ranjan AMizuguchi G, Fitzgerald PC, Wei D, Wang F, Huang Y, Luk E, Woodcock CL, Wu C. (2013) Nucleosome-free Region Dominates Histone Acetylation in Targeting SWR1 to Promoters for H2A.Z Replacement. Cell 154:1232-45. [ pdf ]
Kaneko-Gogo T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, Yoshihara, Y. (2013) Goofy coordinates the acuity of olfactory signaling. The Journal of Neuroscience 33(32), 2987-12996. [ pdf ]
Lee Y-S, Lee S-J. (2013) Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proceedings of the National Academy of Sciences USA 110, E3713–22. [ link ]
Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan S, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL. (2013) piggyBac transposase tools for genome engineering. Proceedings of the National Academy of Sciences USA 110(25):E2279-E2287. [ link ]
Choi KY, Li Y, Sarnovsky R, Craig NL. (2013) Direct interaction between the TnsA and TnsB subunits controls the heteromeric Tn7 transposase. Proceedings of the National Academy of Sciences USA 110(22):E2038-E2045. [ link ]
Rajakumari S, Wu J, Ishibashi, J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metabolism 17(4), 562-574. [ pdf ]
Chang H, Nathans J. (2013) Responses of hair follicle-associated structures to loss of planar cell polarity signaling. Proceedings of the National Academy of Sciences USA E908-E917. [ link ]
Seydoux G. (2013) 'Goldilocks' suppressor screen identifies web of polarity regulators. Nature Cell Biology 15(1):9-10. [ link ] [ pdf ]
Rattner A, Yu H, Williams J, Smallwood PM, Nathans J. (2013) Endothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proceedings of the National Academy of Sciences USA 110: E3830-E3839. [ link ]
He SL, Green R. (2013) Polysome analysis of mammalian cells. Methods in Enzymology 530:183-92. [ link ]
Motegi F, Seydoux G. (2013) The PAR network: redundancy and robustness in a symmetry breaking system. Philosophical Transactions of the Royal Society 368(1629):2013. [ pdf ]
Wang JT, Seydoux G. (2013) Germ cell specification. Advances in Experimental Medicine and Biology 757:17-39. [ pdf ]

2012

Wu H, Williams J, Nathans J. (2012) Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling. eLife 1: e00181. [ link ]
Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW. (2012) The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes and Development 26, 2684-2689. [ link ]
Holland AJ*, Fachinetti D*, Cleveland DW. (2012) An inducible system for the rapid and complete destruction of proteins in mammalian cells. Proceedings of the National Academy of Sciences USA 109, E3350-E3357. [ link ]
Holland AJ, Cleveland DW. (2012) The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. Journal of Clinical Investigation 122, 4325-4328. [ link ]
Julius D, Nathans J. (2012) Signaling by Sensory Receptors. Cold Spring Harb Perspectives in Biology 4:a005991. [ link ]
Holland AJ, Cleveland DW. (2012) Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nature Medicine 18, 1630-1638. [ link ]
Moin SM, Urban S. (2012) Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics. Elife 1, e00173. [ link ]
Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee S-J, Anders RA, Liu JO, Pan D. (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes & Development 26, 1300–1305. [ link ] [ pdf ]
Sebé-Pedrós A, Zheng Y, Ruiz-Trillo I, and Pan D. (2012) Premetazoan origin of the Hippo signaling pathway. Cell Reports, (1): 13-20. [ pdf ]
Roby YA, Bushey MA, Cheng LE, Kulaga HM, Lee S-J, Reed RR. (2012) Zfp423/OAZ mutation reveals the importance of Olf/EBF transcription activity in olfactory neuronal maturation. Journal of Neuroscience 32, 13679–88a. [ link ]
Duan R, Jin P, Luo F, Zhang G, Anderson N, Chen EH. (2012) Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. Journal of Cell Biology 199(1):169-85. [ link ]
Baker RP, Urban S. (2012) Architectural and thermodynamic principles underlying intramembrane protease function. Nature Chemical Biology. 8, 759–768. [ link ]
Yu H, Ye X, Guo N, Nathans J. (2012) Frizzled2 and Frizzled7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development 139: 4383-4394. [ link ]
Lee SJ, Huynh TV, Lee YS, Sebald SM, Wilcox-Adelman SA, Iwamori N, Lepper C, Matzuk MM, Fan CM. (2012) Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proceedings of the National Academy of Sciences USA 109, E2353-2360. [ link ]